4-Methyloxybenzyl chloride → 5-(4-Methoxybenzyloxy)-3-[4-(4-morpholinyl)phenyl]-2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran

HRID 1743211Notes

Reaction equation

HRID 1743211 reaction equation
[CH3:1][C:2]1([CH3:27])[CH:6]([C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[CH:9][CH:8]=2)[C:5]2[C:19]([CH3:26])=[C:20]([OH:25])[C:21]([CH3:24])=[C:22]([CH3:23])[C:4]=2[O:3]1.[CH3:28][O:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34]Cl)=[CH:32][CH:31]=1>>[CH3:28][O:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34][O:25][C:20]2[C:21]([CH3:24])=[C:22]([CH3:23])[C:4]3[O:3][C:2]([CH3:27])([CH3:1])[CH:6]([C:7]4[CH:8]=[CH:9][C:10]([N:13]5[CH2:14][CH2:15][O:16][CH2:17][CH2:18]5)=[CH:11][CH:12]=4)[C:5]=3[C:19]=2[CH3:26])=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 699934-Methyloxybenzyl chlorideHCID 222382542,2,4,6,7-Pentamethyl-3-[4-(4-morpholinyl)phenyl]-2,3-dihydrobenzofuran-5-ol

Product 1

HCID 101847565-(4-Methoxybenzyloxy)-3-[4-(4-morpholinyl)phenyl]-2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuranYield 38%

Procedure

Using 2,2,4,6,7-pentamethyl-3-[4-(4-morpholinyl)phenyl]-2,3-dihydrobenzofuran-5-ol and 4-methoxybenzyl chloride, the title compound was obtained in the same manner as in Example 1.

Sources & evidence

ORD record
ord-3211300709c3479aa33bf39a237284d5
Source dataset
uspto-grants-2006_03
Patent number
US07008950B1

Reaction notes

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