Methyl 4-(bromomethyl)-2-methylbenzoate → Methyl 4-[[3-(4-isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl]oxymethyl]benzoate

HRID 1743218Notes

Reaction equation

HRID 1743218 reaction equation
C[C:2]1([C:17]2[CH:22]=[CH:21][C:20]([CH:23]([CH3:25])[CH3:24])=[CH:19][CH:18]=2)[C:6]2[C:7]([CH3:14])=[C:8]([OH:13])[C:9]([CH3:12])=[C:10]([CH3:11])[C:5]=2[O:4][C:3]1([CH3:16])[CH3:15].Br[CH2:27][C:28]1[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[C:30](C)[CH:29]=1>>[CH:23]([C:20]1[CH:21]=[CH:22][C:17]([CH:2]2[C:6]3[C:7]([CH3:14])=[C:8]([O:13][CH2:27][C:28]4[CH:29]=[CH:30][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:36][CH:37]=4)[C:9]([CH3:12])=[C:10]([CH3:11])[C:5]=3[O:4][C:3]2([CH3:16])[CH3:15])=[CH:18][CH:19]=1)([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 19372658Methyl 4-(bromomethyl)-2-methylbenzoateHCID 22238295Methyl 3-(4-isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ol

Product 1

HCID 10116252Methyl 4-[[3-(4-isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl]oxymethyl]benzoateYield 82%

Procedure

Using methyl 3-(4-isopropylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ol and methyl 4-(bromomethyl)methylbenzoate, the title compound was obtained in the same manner as in Example 1.

Sources & evidence

ORD record
ord-694c0f5308e441baabd49f87c61562f2
Source dataset
uspto-grants-2006_03
Patent number
US07008950B1

Reaction notes

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