HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1743266Generated: October 27, 2026
Carbon tetrabromide → 2-Trimethylsilanylethyl 4-bromomethyl-piperidine-1-carboxylate
https://huagongshe.com/reaction/1743266
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-(Trimethylsilyl)ethyl 4-(hydroxymethyl)piperidine-1-carboxylate | HCID 11368948 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Trimethylsilanylethyl 4-bromomethyl-piperidine-1-carboxylate | HCID 22238394 | — |
Reaction Steps
19.9 g of 2-trimethylsilanylethyl 4-hydroxymethylpiperidine-1-carboxylate were dissolved in 600 ml of THF. After cooling to 0° C., 50.7 g of tetrabromomethane were added. Then 42.1 g of triphenylphosphine were added in 4 portions at intervals each of 20 min. The mixture was allowed to reach room temperature and was stirred for 14 h. The solvent was then removed in vacuo, and the residue was chromatographed on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07008957B2 |
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| Source dataset | uspto-grants-2006_03 |
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| ORD ID | ord-48b3313e1087426b80b264767c1bb6bb |
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| Source note | uspto-grants-2006_03 |
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