Ammonia → HCID 69651241, compound

HRID 1743272Notes

Reaction equation

HRID 1743272 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@:9]1([CH2:22][CH:23]2[CH2:28][CH2:27][N:26]([C:29]([O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])=[O:30])[CH2:25][CH2:24]2)[C:16](=[O:17])[N:15]2[C@@H:11]([S:12][CH2:13][C@H:14]2[C:18]([O:20]C)=O)[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:38]>>[C:1]([O:5][C:6]([NH:8][C@@:9]1([CH2:22][CH:23]2[CH2:28][CH2:27][N:26]([C:29]([O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])=[O:30])[CH2:25][CH2:24]2)[C:16](=[O:17])[N:15]2[C@@H:11]([S:12][CH2:13][C@H:14]2[C:18](=[O:20])[NH2:38])[CH2:10]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 91000600HCID 91000600, compound

Product 1

HCID 69651241HCID 69651241, compound

Procedure

340 mg of methyl (3R,6R,7aS)-6-tert-butoxycarbonylamino-5-oxo-6-[1-(2-trimethylsilanylethoxycarbonyl)piperidin-4-ylmethyl]hexahydropyrrolo[2,1-b]thiazole-3-carboxylate were dissolved at 0° C. in 35 ml of an ammonia-saturated methanol solution. The mixture was allowed to reach room temperature in the course of 4 h, and then the solvents were removed in vacuo. The residue was employed without further purification in the next reaction.

Workup

  1. customto reach room temperature in the course of 4 h
  2. customthe solvents were removed in vacuo
  3. customThe residue was employed without further purification in the next reaction

Sources & evidence

ORD record
ord-fb0bb5406f024e96ae3fe595533c137f
Source dataset
uspto-grants-2006_03
Patent number
US07008957B2

Reaction notes

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