反应详情

温度

120 °C

To a solution of 2-nitroaniline (20 g, 144.8 mmol) dissolved in 400 ml of dry-ethanol in a 500 ml round bottom flask was added dimethylethoxymethylene malonate (34 g, 159.3 mmol). The solution was heated and refluxed for 6 hrs at 120° C. with stirring. The reaction was monitered by TLC (n-hexane/ethyl acetate=3/1). After completing the reaction and cooling to room temperature, the resulting precipate was collected by filtration, and the residue was washed three times with 100 ml of n-hexane to give 2-[(2-Nitro-phenylamino)-methylene]-malonic acid diethyl ester (31 g, 100.6 mmol, yield 69%).

1. dry with materialof dry-ethanol in a 500 ml round bottom flask
2. temperatureThe solution was heated
3. customthe reaction
4. temperaturecooling to room temperature
5. filtrationthe resulting precipate was collected by filtration
6. washthe residue was washed three times with 100 ml of n-hexane