3-(Trifluoromethyl)benzylamine → HCID 10068907, compound

HRID 1743298Notes

Reaction equation

HRID 1743298 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1Cl)=[CH:13][CH:12]=[CH:11][C:10]=2[N+:17]([O-])=O)=[O:5])[CH3:2].[F:20][C:21]([F:31])([F:30])[C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH2:26]>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:26][CH2:25][C:24]1[CH:27]=[CH:28][CH:29]=[C:22]([C:21]([F:20])([F:30])[F:31])[CH:23]=1)=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:17])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 11196760Ethyl 4-chloro-8-nitroquinoline-3-carboxylate

Product 1

HCID 10068907HCID 10068907, compoundYield 80%

Procedure

The compound prepared in Example 3 was reacted with 3-trifluoromethyl-benzylamine according to the method as described in Example 4 and the obtained compound was treated as described in Example 14 to prepare the title compound (yield 80%).

Workup

  1. additionthe obtained compound was treated

Sources & evidence

ORD record
ord-130b8c5ab684443d98d0ae18f33cca45
Source dataset
uspto-grants-2006_03
Patent number
US07009053B2

Reaction notes

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