Acetic Anhydride → HCID 22238064, compound

HRID 1743385Notes

Reaction equation

HRID 1743385 reaction equation
[C:1](OC(=O)C)(=[O:3])C.[CH3:8][CH:9]1[CH2:17][C:16]2[C:11](=[C:12]([CH3:20])[C:13]([CH3:19])=[C:14]([OH:18])[CH:15]=2)[NH:10]1>C(O)=O>[OH:18][C:14]1[CH:15]=[C:16]2[C:11](=[C:12]([CH3:20])[C:13]=1[CH3:19])[N:10]([CH:1]=[O:3])[CH:9]([CH3:8])[CH2:17]2

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22238098HCID 22238098, compound

Product 1

HCID 22238064HCID 22238064, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Acetic anhydride (0.76 mL, 8.1 mmol) was added to formic acid (4 mL), and the mixture was stirred at room temperature for 15 minutes. To this solution was added 2,3-dihydro-2,6,7-trimethyl-1H-indole-5-ol (0.71 g, 4.0 mmol), and the mixture was stirred at room temperature for 5 hours. Ice was added to the reaction mixture, and precipitated solid was filtered to obtain 0.40 g of the title compound.

Workup

  1. stirringthe mixture was stirred at room temperature for 5 hours
  2. additionIce was added to the reaction mixture
  3. customprecipitated solid
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-bbaa5d85196d44da98a1b9ee0d7f8902
Source dataset
uspto-grants-2006_03
Patent number
US07008940B1

Reaction notes

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