4-Amino-3,5-diiodobenzoic acid → HCID 22237384, compound

HRID 1743516Notes

Reaction equation

HRID 1743516 reaction equation
[NH2:1][C:2]1[C:10](I)=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1I.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1>>[NH2:1][C:2]1[C:10]([C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([C:14]([F:25])([F:24])[F:13])[CH:20]=2)=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[C:19]1[CH:18]=[CH:17][CH:16]=[C:15]([C:14]([F:25])([F:24])[F:13])[CH:20]=1

Participants

3

Reactant 2

HCID 164604-Amino-3,5-diiodobenzoic acidHCID 27343883-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 22237384HCID 22237384, compound

Procedure

2′-Amino-3,3″-bis-trifluoromethyl-[1,1′:3′1″]terphenyl-5′-carboxylic acid was prepared as an off white solid (0.992 g, 94%) from 4-amino-3,5-diiodobenzoic acid and 3-trifluoromethylphenyl boronic acid using a procedure similar to step 1 of Example 175. 1H NMR (CDCl3) δ 7.90 (s, 2H); 7.78 (m, 2H); 7.74–7.60 (m, 6H); 4.24 (bs, 2H).

Sources & evidence

ORD record
ord-d6ed3935cdea4e33814d7224843c1031
Source dataset
uspto-grants-2006_03
Patent number
US07008636B2

Reaction notes

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