HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(4-(Trifluoromethylthio)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Bromo-1,1,1-trifluoropropane | HCID 2725114 | — |
| Reactant | (4-(Trifluoromethylthio)benzyl)malononitrile | HCID 22234991 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-(Trifluoromethylthio)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235061 | 11% |
Reaction Steps
Using 0.50 g of (4-(trifluoromethylthio)benzyl)malononitrile, 10 ml of N,N-dimethylformamide, 0.09 g of sodium hydride (60% in oil), and 0.38 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.03 g of 2-(4-(trifluoromethylthio)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (13)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07011838B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-e37fff3772ef4232b5b6cd5d4cc32213 |
| Source note | uspto-grants-2006_03 |