HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(2-Chloro-4-nitrobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | alpha,2-Dichloro-4-nitrotoluene | HCID 3016511 | — |
| Reactant | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(2-Chloro-4-nitrobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235071 | 46% |
Reaction Steps
Using 0.21 g of 2-chloro-4-nitrobenzyl chloride, 3 ml of N,N-di-methylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.15 g of 2-(2-chloro-4-nitrobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (38)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07011838B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-1e8b6dc8154343cd8db4eb915afa9524 |
| Source note | uspto-grants-2006_03 |