HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 2-(2,2,2-Trifluoroethyl)-2-(4-(trifluoromethyl)benzyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,2,2-Trifluoroethyl trifluoromethanesulfonate | HCID 80366 | — |
| Reactant | (4-(Trifluoromethyl)benzyl)malononitrile | HCID 10656743 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(2,2,2-Trifluoroethyl)-2-(4-(trifluoromethyl)benzyl)malononitrile | HCID 22235054 | 44% |
Reaction Steps
Using 1.0 g of (4-(trifluoromethyl)benzyl)malononitrile, 8 ml of N,N-dimethylformamide, 0.73 g of cesium carbonate, and 1.0 g of 2,2,2-trifluoroethyl trifluoromethanesulfonate, and according to the process described in the Production Example 1, there was obtained 0.58 g of 2-(2,2,2-trifluoroethyl)-2-(4-(trifluoromethyl)benzyl)malononitrile (the present compound (72)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07011838B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-73cb679fd1d641f1b259f52d99a52f14 |
| Source note | uspto-grants-2006_03 |