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m,alpha-Dichlorotoluene → 2-(3-Chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m,alpha-Dichlorotoluene | HCID 12103 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(3-Chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235068 | 42.1% |
反応手順
Using 0.16 g of 3-chlorobenzyl chloride, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.12 g of 2-(3-chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (82)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07011838B2 |
| 出典データセット | uspto-grants-2006_03 |
| ORD ID | ord-7780d53e712842c2bdec5430ed14aff6 |
| 出典メモ | uspto-grants-2006_03 |