HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 22235374, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 22235550 | HCID 22235550 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | HCID 22235374 | HCID 22235374 | 739.7% |
Reaction Steps
To a solution of tert-butyl 3-[3-(4-cyanoanilino)propyl]-3,8-diazabicyclo[3.2.1]octane-8-carboxylate (4.7 g, 2.7 mmol; from step (a) above) in CH2Cl2 (600 mL) was added TFA (90 mL). The resulting solution was stirred for 1 h and concentrated in vacuo. Flash chromatography on silica gel eluting with CH2Cl2:MeOH:concentrated NH4OH (94:5:1) gave 2.7 g (79%) of the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07012074B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-a7c886d5cef041a18806ed8bd8682500 |
| Source note | uspto-grants-2006_03 |