Potassium Carbonate → HCID 22235448, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate (7.1 g, 33.4 mmol; from Preparation B above) in DMF (120 mL) was added K2CO3 (5.1 g, 36.8 mmol) and 4-(4-cyanophenyl)-4-(3,4-dimethoxyphenoxy)butyl methanesulfonate (13.9 g, 34.4 mmol; see Preparation E, step (c) above). The resulting solution was heated to 90° C., stirred 4 h, cooled and concentrated in vacuo. The residue was suspended in H2O and extracted with CH2Cl2 (3×). The combined organics were dried (Na2SO4), filtered and concentrated in vacuo. Flash chromatography on silica gel eluting with CH2Cl2:MeOH (98:2) gave 17.3 g (99%) of the title compound.

Provenance & Evidence