Acetonitrile → HCID 22235350, compound

Participants

Reaction Conditions

Reaction Steps

The free base (0.9 g, 4.1 mmol) was dissolved in CH3CN (50 mL) and 4-(2-bromoethoxy)isophthalonitrile (1.17 g, 4.7 mmol; from step (a) above) and K2CO3 (0.93 g, 6.75 mmol) were added. The mixture was stirred at 70° C. for 6 h, the solids were filtered off and the residue was evaporated and purified by column chromatography (CHCl3:MeOH, 95:5) to give the sub-title compound in 84% yield.

Provenance & Evidence