HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1743723Generated: October 26, 2026
1,1'-(Azodicarbonyl)dipiperidine → 4-{1-[4-(Tetrahydro-2H-pyran-2-yloxy)phenoxy]-3-butenyl}benzonitrile
https://huagongshe.com/reaction/1743723
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | 4-(1-Hydroxy-3-butenyl)benzonitrile | HCID 11019345 | — |
| Reactant | 4-[(Oxan-2-yl)oxy]phenol | HCID 11745519 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-{1-[4-(Tetrahydro-2H-pyran-2-yloxy)phenoxy]-3-butenyl}benzonitrile | HCID 22235671 | 68.7% |
Reaction Steps
4-(Tetrahydro-2H-pyran-2-yloxy)phenol (19.0 g, 0.1 mol) and 4-(1-hydroxy-3-butenyl)benzonitrile (17.8 g, 0.1 mol) was mixed in toluene, and cooled to 0° C. (under nitrogen). TBP (22.9 g, 0.11 mol) was added, followed by ADDP. The mixture was stirred at rt overnight, filtered, and evaporated. Purification by chromatography on silica gave 24 g (68.7%) of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07012074B2 |
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| Source dataset | uspto-grants-2006_03 |
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| ORD ID | ord-c55d5a9310124f4fb97feca2aff36e68 |
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| Source note | uspto-grants-2006_03 |
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