HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 4-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | (R)-4-(Oxiran-2-ylmethoxy)benzonitrile | HCID 6934186 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile | HCID 30072096 | 91% |
Reaction Steps
4-[(2R)-Oxiranylmethoxy]benzonitrile (14.65 g, 83.6 mmol; prepared as described in international patent application WO 99/31100) was mixed with conc. NH4OH (64 mL) and 87 mL of isopropanol. The mixture was stirred at r.t for 18 h. The reaction mixture was filtered and the filtrate evaporated to give 14.6 g (91%) of the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07012074B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-2898c09fcc9b474dbeffd4f6f392d00f |
| Source note | uspto-grants-2006_03 |