5-Bromo-2-nitrothiophene-3-carboxamide → 2-Amino-5-[4-(3-fluorooxetan-3-yl)phenyl]thiophene-3-carboxamide
Reaction equation
[Br:1][c:2]1[s:3][c:4]([N+:5]([O-:6])=[O:7])[c:8]([C:9]([NH2:10])=[O:11])[cH:12]1.[F:13][C:14]1([c:18]2[cH:19][cH:20][c:21](-[c:24]3[cH:25][c:26]([C:32](=[O:33])[NH2:34])[c:27]([N+:29]([O-:30])=[O:31])[s:28]3)[cH:22][cH:23]2)[CH2:15][O:16][CH2:17]1>>[F:13][C:14]1([c:18]2[cH:19][cH:20][c:21](-[c:24]3[cH:25][c:26]([C:32](=[O:33])[NH2:34])[c:27]([NH2:29])[s:28]3)[cH:22][cH:23]2)[CH2:15][O:16][CH2:17]1Participants
3
Sources & evidence
- ORD record
- ord-497f72f2403446c38d54c44b3bd439cc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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