[1-(2-Methoxy-2-methylpropyl)piperidin-4-yl]methylamine → 5-Amino-6-chloro-2-methyl-N-{[1-(2-methoxy-2-methylpropyl)piperidin-4-YL]methyl}imidazo[1,2-A]pyridine-8-carboxamide

HRID 1743822Notes

Reaction equation

HRID 1743822 reaction equation
C[C:2]1[N:6]2[C:7]([NH2:15])=[C:8]([Cl:14])[CH:9]=[C:10]([C:11]([OH:13])=O)[C:5]2=[N:4][C:3]=1[CH3:16].[CH3:17][O:18][C:19]([CH3:30])([CH3:29])[CH2:20][N:21]1[CH2:26][CH2:25][CH:24]([CH2:27][NH2:28])[CH2:23][CH2:22]1>>[NH2:15][C:7]1[N:6]2[CH:2]=[C:3]([CH3:16])[N:4]=[C:5]2[C:10]([C:11]([NH:28][CH2:27][CH:24]2[CH2:23][CH2:22][N:21]([CH2:20][C:19]([O:18][CH3:17])([CH3:29])[CH3:30])[CH2:26][CH2:25]2)=[O:13])=[CH:9][C:8]=1[Cl:14]

Participants

3

Reactant 2

HCID 22236492[1-(2-Methoxy-2-methylpropyl)piperidin-4-yl]methylamineHCID 67550158Methyl 5-amino-6-chloro-2-methylimidazo[1,2-a]pyridine-8-carboxylic acid

Product 1

HCID 99787705-Amino-6-chloro-2-methyl-N-{[1-(2-methoxy-2-methylpropyl)piperidin-4-YL]methyl}imidazo[1,2-A]pyridine-8-carboxamide

Procedure

The title compound was prepared according to the procedure described in the step 6 in EXAMPLE 1 from 5-amino-6-chloro-2-methylimidazo[1,2-a]pyridine-8-carboxylic acid (EXAMPLE 1, Step 5) and [1-(2-methoxy-2-methylpropyl)piperidin-4-yl]methylamine (EXAMPLE 4, Step 6).

Sources & evidence

ORD record
ord-33a9d6908fc0486c8338f81211c9e7e6
Source dataset
uspto-grants-2006_03
Patent number
US07012080B2

Reaction notes

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