Cycloheptanone → HCID 10378356, compound

Participants

Reaction Steps

To a solution of 4-methyl-3,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-1-ylamine (1.80 g, 9.4 mmol) in 1-propanol (100 mL) was added cycloheptanone (5.28 g, 47.0 mmole), followed by p-toluenesulfonic acid monohydrate (3.2 g, 16.8 mmole), and the resulting reaction mixture was refluxed for 40 hours. The reaction mixture was cooled to room temperature and solvent removed in vacuo to produce a brown residue. The residue was diluted with ethyl acetate (300 mL) and washed with saturated aqueous sodium bicarbonate (150 mL), saturated aqueous sodium chloride (150 mL), dried (sodium sulfate) and concentrated in vacuo. Purification by flash column chromatography (silica gel, ethyl acetate:hexanes 1:1) provided 1.20 g of the title compound as a light yellow solid. 80 mg of this was treated with one equivalent of fumaric acid in ethanol to form a fumarate salt, mp 190-192° C. MS (ESI) m/z 269 ([M+H]+).

Provenance & Evidence