{[2-(4-Chloro-2-nitro-phenyl)-ethyl]-methyl-amino}-acetic Acid Ethyl Ester → {[2-(4-chloro-2-nitro-phenyl)-ethyl]-methyl-amino}-acetic Acid

Participants

Reaction Conditions

Reaction Steps

{[2-(4-Chloro-2-nitro-phenyl)-ethyl]-methyl-amino}-acetic acid ethyl ester (22.5 g, 0.075 mole) dissolved in concentrated hydrobromic acid (48 wt. % in water, 200 mL) was allowed to stir at 70° C. overnight and then reduced to a small volume in vacuo. The residue oil was taken up in acetonitrile and the solution was evaporated in vacuo. This procedure was repeated until the water was removed and a crystalline residue remained. This material (18.5 g) was used in the next step without further purification.

Provenance & Evidence