Cyclohexanepropionaldehyde → (5R)-12-(2-cyclohexylethyl)-5-ethyl-9-fluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione

Participants

Role	Name	HCID	Charge
Reactant	Cyclohexanepropionaldehyde	HCID 78070	—
Reactant	(5R)-5-ethyl-9-fluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione	HCID 9929755	—
Product	(5R)-12-(2-cyclohexylethyl)-5-ethyl-9-fluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione	HCID 69478257	—

The product of Example 2 is treated with 3-cyclohexylpropanal according to a procedure similar to Stage 13e in order to produce the expected solid.