Sodium Bicarbonate → HCID 22236886, compound

Participants

Reaction Steps

To a solution of 4.72 g of the compound obtained in Step 3 in 100 ml of methanol was added 40 ml of IN HCl solution, and the resulting mixture was stirred for 6 hours. After the reaction was completed, the reaction solution was neutralized with sodium hydrogen carbonate solution, distilled under reduced pressure to remove methanol therefrom, and extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and the residue thus obtained was purified by a silica gel column chromatography using a mixture of ethyl acetate and n-hexane of 1:2 to obtain 3.24 g of the title compound as an oil.

Provenance & Evidence