HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitromethane → HCID 22236902, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Ethyl 3-(pyridin-2-yl)but-2-enoate | HCID 69594025 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 22236902 | HCID 22236902 | — |
Reaction Steps
A solution of 6 g of the compound obtained in Step 1, 3.36 ml of nitromethane and 4.26 ml of DBU dissolved in 120 ml of acetonitrile was heated to reflux for 36 hours. After the reaction was completed, the reaction solution was distilled under reduced pressure. The residue thus obtained was purified by a silica gel column chromatography using a mixture of ethyl acetate and n-hexane of 1:9 to obtain 1.8 g of the title compound as a syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07012144B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-995470827d67461cbbf0be5af4c91273 |
| Source note | uspto-grants-2006_03 |