HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ketoprofen → HCID 131725382, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ketoprofen | HCID 3825 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Hydratropoyl chloride | HCID 2760403 | — |
| Reactant | HCID 22236856 | HCID 22236856 | — |
| Product | HCID 131725382 | HCID 131725382 | 99% |
Reaction Steps
The procedure is identical to that for the synthesis of α-phenylpropionic acid chloride. Starting with 4.69 g (M=254.3 g, 18.4 mmol) of ketoprofen and 13.4 ml (10 eq) of thionyl chloride, 5.26 g (M=272.8 g, 18.2 mmol) of ketoprofen chloride are obtained, i.e. a yield of 99%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07012138B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-98b191af8b7f4d53843902db1ff36101 |
| Source note | uspto-grants-2006_03 |