Triethylamine → HCID 69584822, compound

Participants

Reaction Steps

To a 100 mL round-bottomed flask equipped with condenser and N2 inlet were added 157 mg (0.50 mmol) 6-(4-carboxymethylnaphthalen-1-yl)-pyridin-2-ylamine, 95 mg (0.50 mmol) N-phenethylpiperazine, 96 mg (0.50 mmol) N-ethyl, N-3-dimethylaminopropyl-carbodiimide, 0.230 mL (1.65 mmol) triethylamine, 10 mg N-hydroxybenzotriazole, and 7 mL dry acetonitrile. The reaction was stirred at room temperature 12 hours (LCMS showed P+1=451 and TLC showed Rf=0.3 in 10% methanol/methylene chloride), then evaporated and the residue chromatographed on silica gel using methanol/methylene chloride as eluant to afford the product as a foam, 230 mg (˜100%).

Provenance & Evidence