1-(Bicyclo[2.2.1]hept-5-en-2-yl)-2,2,4,4,4-pentafluorobutane-1,3,3-triol → HCID 22237068, compound

Participants

Reaction Steps

A mixture of 288 g of 1-(5-norbornene-2-yl)-2,2,4,4,4-pentafluorobutane-1,3,3-triol (synthesized according to [Synthetic example 1]) and 1500 g of toluene was heated under reflux for 2 hours, removing the water produced. After cooling, toluene was removed by evaporation under reduced pressure, and 270 g of 1-hydroxy-1-(5-norbornene-2-yl)-2,2,4,4,4-pentafluorobutane-3-one was obtained (quantitative yield).

Provenance & Evidence