Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Phosphorous acid | HCID 107909 | — |
| Reactant | HCID 9856556 | HCID 9856556 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 22237001 | HCID 22237001 | 85% |
Reaction Steps
To a solution of hydroxy(1-acetyl-4,6-dimethylindolin-5-yl)acetic acid obtained in Example 1 (280 g) in acetic acid (1120 ml) were added phosphorous acid (130 g) and potassium iodide (17.6 g), and the resulting mixture was stirred for 2 hours at 100–107° C. After cooling to 50° C., water (1120 ml) was added, and crystals precipitated were separated by filtration and dried to afford (1-acetyl-4,6-dimethylindolin-5-yl)acetic acid (223 g, yield: 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07012147B2 |
|---|
| Source dataset | uspto-grants-2006_03 |
|---|
| ORD ID | ord-d5defd3a5e644c64a25fa3499f4ef8dd |
|---|
| Source note | uspto-grants-2006_03 |
|---|
