Hydrochloric Acid → HCID 69152255, compound

Participants

Reaction Steps

To methyl 2-[(5-bromo-2-pyrimidinyl)amino]-4-methylpentanoate (1.27 g, 4.2 mmol) in MeOH (50 mL) was added an aqueous solution of LiOH (2 M, 21 mL, 42 mmol) and the reaction was stirred for 5 hours. The reaction was neutralized with aqueous 10% HCl (pH of 6–7) and concentrated to a minimum volume in vacuo. Brine was added and the product was extracted with EtOAc (3×), dried on Na2SO4, concentrated in vacuo, and stripped with MePh (3×) to afford N-(5-bromo-2-pyrimidinyl)leucine which was used as such in the next step.

Provenance & Evidence