反应详情

To a solution of methyl 1-[(2-bromophenyl)sulfanyl]cyclohexanecarboxylate (89 mg, in MeOH (3 mL) was added 1 M NaOH (1 mL). The mixture was stirred at room temperature for 2 days, then at 65° C. for 6 h. The mixture was then concentrated and the residue was partitioned between ethyl acetate and 1 M HCl. The organic phase was washed with brine, dried over MgSO4 and concentrated to give 1-[(2-bromophenyl)sulfanyl]cyclohexanecarboxylic acid.

1. waitat 65° C. for 6 h
2. concentrationThe mixture was then concentrated
3. customthe residue was partitioned between ethyl acetate and 1 M HCl
4. washThe organic phase was washed with brine
5. dry with materialdried over MgSO4
6. concentrationconcentrated