HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 2-(4-bromophenyl)-N,N-dimethylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Benzeneacetic acid, 4-bromo- | HCID 74654 | — |
| Reactant | PyBOP | HCID 2724699 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-bromophenyl)-N,N-dimethylacetamide | HCID 4631595 | 51.1% |
Reaction Steps
To a suspension of 4-bromophenylacetic acid (2.0 g, 9.3 mmol) and PyBOP (4.8 g, 9.3 mmol) in DMF (15 mL) was added dimethylamine (2 M solution in THF, 12 mL, 24 mmol). The solution was stirred overnight, then diluted with ether and washed with 1 M HCl, saturated aqueous NaHCO3 and brine to give 1.15 g 2-(4-bromophenyl)-N,N-dimethylacetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07012075B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-1f8ea3b06303450eb827abb53f79a219 |
| Source note | uspto-grants-2006_03 |