Aminoacetonitrile → HCID 86594560, compound

Participants

Reaction Steps

Ester hydrolysis and coupling with aminoacetonitrile as described in example 4 provided N2-(4-bromoisothiazol-3-yl)-N1-(cyanomethyl)-L-leucinamide. N2-(4-bromoisothiazol-3-yl)-N1-(cyanomethyl)-L-leucinamide was then treated with 4-[4-(tert-butoxycarbonyl)-1-piperazinyl]phenylboronic acid (prepared as described in Example 1) as described in Example 1 to afford, after BOC removal with methanesulfonic acid as described in Example 10, N1-(cyanomethyl)-N2-[4-(4-piperazin-1-ylphenyl)isothiazol-3-yl]-L-leucinamide. MS (+ESI): 413.2 [M+1]+.

Provenance & Evidence