HCID 22235993, compound → HCID 22235841, compound

Participants

Reaction Steps

Using the procedure described in Example 1 where tert-butyl 4-{4′-[((1S)-1-{[(cyanomethyl)amino]carbonyl}-3-methylbutyl)amino][1,1′-biphenyl]-4-yl}-1-piperazinecarboxylate is substituted for tert-butyl 4-[4′-({2-[(cyanomethyl)amino]-1-[(1-methylcyclopropyl)methyl]-2-oxoethyl}thio)-1,1′-biphenyl-4-yl]piperazine-1-carboxylate, N-(cyanomethyl)-3-(1-methylcyclopropyl)-2-[(4′-piperazin-1-yl-1,1′-biphenyl-4-yl)thio]propanamide was obtained after crystallization in EtOAc and hexane (1:2) as a beige solid. MS (+ESI): 435.2 [M+1]+.

Provenance & Evidence