Triethylamine → HCID 86594584, compound

Participants

Reaction Steps

To (4S)-1-(3-bromophenyl)-4-methyl-L-proline (1.35 g, 4.75 mmol), PyBOP (2.72 g, 5.23 mmol), aminoacetonitrile hydrochloride (968 mg, 10.46 mmol) in dry DMW (30 mL) under dry nitrogen was added triethylamine (2.35 mL, 16.63 mmol) dropwise and the reaction was stirred overnight. Aqueous sat. NaHCO3 was added and the product extracted with Et2O (2×), dried over Na2SO4, concentrated in vacuo and purified by flash chromatography over silica gel (EtOAc/Hex, 35/75, then 4/6) to afford (4S)-1-(3-bromophenyl)-N-(cyanomethyl)-4-methyl-L-prolinamide.

Provenance & Evidence