Sodium Carbonate → HCID 9801001, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.00 eq. of (4) in 1 mL toluene is treated with 10 mole percent tetrakis(triphenylphospine) palladium under nitrogen at room temperature. To this solution is added directly 2.50 eq. of 4-phenoxyphenyl boronic acid at room temperature and then 1 mL Na2CO3 (1.0 M) solution. The reaction vial is capped and the reaction stirred under nitrogen at 90° C. for 10 hours. The toluene layer is separated and removed under reduced pressure, and the resulting oil is purified via flash chromatography to provide (5).

Provenance & Evidence