Sodium Hydroxide → 4-Trifluoromethylnicotinamide

Participants

Reaction Steps

3-[(4,4,4-Trifluoro-3-oxo-1-butenyl)amino]-2-propenenitrile (a high-polar compound IIb; 2.10 g, 11 mmol) was dissolved in methanol (15 ml), and sodium hydroxide (680 mg, 17 mmol) was added. The mixture was heated under reflux for 6 hours. The reaction solution was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (a eluting solvent: hexane/acetone=1/1) to obtain 1.26 g (yield 60.1%) of the title compound.

Provenance & Evidence