HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Trifluoromethylnicotinoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Pyridinecarboxylic acid, 4-(trifluoromethyl)- | HCID 2777549 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-Trifluoromethylnicotinoyl chloride | HCID 11790465 | 90.1% |
Reaction Steps
4-Trifluoromethylnicotinic acid (50.09 g, 0.262 mol) was suspended in benzene (250 ml), and thionyl chloride (38.2 ml, 0.524 mol) and N,N-dimethylformamide (0.1 ml) were added. The mixture was refluxed for 3 hours. The reaction mixture was concentrated, and the residue was distilled under reduced pressure to obtain 49.45 g (yield 90.1%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015236B2 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-8fce0577896845a1a44c780a1913314a |
| Source note | uspto-grants-2006_03 |