Ethanol → HCID 22228634, compound

Participants

Reaction Steps

3.1 g (14 mmol) of 2-(6-hydroxy-5,7-dimethyl-1-benzofuran-3-yl) acetic acid are heated at reflux overnight in 1.72 ml of conc. sulfuric acid in 861 ml of ethanol. The mixture is concentrated down to 50 ml and then diluted with water and ethyl acetate; the phases are separated and the aqueous phase is extracted with ethyl acetate. The combined phases are washed with a saturated solution of NaCl, dried over sodium sulfate and concentrated. Chromatographic purification (dichloromethane) yields 2.6 g (75%) of ethyl 2-(6-hydroxy-5,7-dimethyl-1-benzofuran-3-yl)acetate.

Provenance & Evidence