Ethanethiol → HCID 22228637, compound

Participants

Reaction Steps

0.74 g (2.09 mmol) of ethyl 2-[6-(4-methoxyphenoxy)-5,7-dimethyl-1-benzofuran-3-yl]acetate, dissolved in 1 ml of dichloromethane, is [lacuna], at 0° C., to a solution of 0.84 g (6.26 mmol) of aluminum chloride and 0.65 g (10.44 mmol) of ethanethiol in 10 ml of dichloromethane. The reaction mixture is stirred overnight at room temperature, after which the solvent is removed in vacuo and the residue is subjected to chromatographic purification (cyclohexane/ethyl acetate=5.1). 0.52 g (73%) of ethyl 2-[6-(4-hydroxyphenoxy)-5,7-dimethyl-1-benzofuran-3-yl]acetate is obtained.

Provenance & Evidence