4-(3-(Diethylamino)propoxy)-3-fluoroaniline → HCID 178419008, compound

HRID 1744359Notes

Reaction equation

HRID 1744359 reaction equation
[CH2:1]([N:3]([CH2:16][CH3:17])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[F:15])[CH3:2].[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:20]=1[C:21](=[CH:29]O)[C:22](=[O:28])[NH:23]2>>[CH2:16]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][CH:29]=[C:21]2[C:20]3[C:24](=[CH:25][CH:26]=[CH:27][C:19]=3[F:18])[NH:23][C:22]2=[O:28])=[CH:10][C:9]=1[F:15])[CH3:17]

Participants

3

Reactant 2

HCID 219747414-(3-(Diethylamino)propoxy)-3-fluoroanilineHCID 178418878HCID 178418878, compound

Product 1

HCID 178419008HCID 178419008, compoundYield 67.4%

Procedure

In a manner similar to that described in Example 231, 4-(3-Diethylamino-propoxy)-3-fluoro-phenylamine (720 mg, 1.5 equiv.) and 4-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (358 mg, 2.00 mmol) are reacted to give the named compound as a yellow solid (541 mg, 67%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-a885a8d062e34a4688d8212c40f980b1
Source dataset
uspto-grants-2006_03
Patent number
US07015220B2

Reaction notes

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