反应详情

Example 298–301 are prepared by substituting the appropriate 6′-fluoro or 5′-chloro or 5′-fluoro or 4′-fluoro substituted 1,3-dihydro-indol-2-one for the 1,3-dihydro-indol-2-one and N-(3-morpholin-4-yl-propyl)-benzene-1,4-diamine (used in the preparation of Example 297) for aniline in the reaction of Example 1.

1. customExample 298–301 are prepared
2. customin the reaction of Example 1