3-Fluoropyrrolidine hydrochloride → HCID 178418914, compound

HRID 1744385Notes

Reaction equation

HRID 1744385 reaction equation
I[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][CH:13]=[C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[NH:16][C:15]2=[O:23])=[CH:8][CH:7]=1.Cl.[F:25][CH:26]1[CH2:30][CH2:29][NH:28][CH2:27]1>>[F:25][CH:26]1[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([NH:12][CH:13]=[C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[NH:16][C:15]3=[O:23])=[CH:8][CH:7]=2)[CH2:27]1

Participants

3

Reactant 2

HCID 219752283-Fluoropyrrolidine hydrochlorideHCID 178418721HCID 178418721, compound

Product 1

HCID 178418914HCID 178418914, compound

Procedure

In a manner similar to that described in Example 217, 3-{[4-(3-Iodo-propoxy)-phenylamino]-methylene}-1,3-dihydro-indol-2-one and 3-fluoro-pyrrolidine hydrochloride (226 mg, 1.2 equiv.) (prepared by the method of Giardina, G et al, Synlett (1995), (1), 55–7) are converted to the named compound as a slightly brownish yellow solid (258 mg, 45%).

Workup

  1. customprepared by the method of Giardina, G et al, Synlett (1995), (1), 55–7)

Sources & evidence

ORD record
ord-1e3b0e77cbf34e7b9b511e16a9fb45cf
Source dataset
uspto-grants-2006_03
Patent number
US07015220B2

Reaction notes

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