3-(Dimethylamino)phenol → HCID 22229227, compound

HRID 1744451Notes

Reaction equation

HRID 1744451 reaction equation
[CH3:1][N:2]([CH3:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.C([O:13][C:14](=O)[C:15]([C:27]#[N:28])=[CH:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[CH:18]=1)C>>[C:27]([C:15]1[C:14](=[O:13])[O:9][C:5]2[C:6]([C:16]=1[C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[CH:18]=1)=[CH:7][CH:8]=[C:3]([N:2]([CH3:10])[CH3:1])[CH:4]=2)#[N:28]

Participants

3

Reactant 2

HCID 74213-(Dimethylamino)phenolHCID 2732672HCID 2732672, compound

Product 1

HCID 22229227HCID 22229227, compoundYield 0.4%

Procedure

The title compound was prepared from 3-dimethylaminophenol and 3-(3,5-dimethoxyphenyl)-2-cyano-acrylic acid ethyl ester by a procedure similar to that described for Example 16 in 0.4% yield. 1H NMR (DMSO-d6): 7.09 (d, J=8.7 Hz, 1H), 6.80 (d, J=7.5 Hz, 1H), 6.73-6.71 (m, 2H), 6.65 (d, J=2.1 Hz, 2H), 3.80 (s, 6H), 3.11 (s, 6H).

Sources & evidence

ORD record
ord-e713a68b35c9495bb715765345b57d96
Source dataset
uspto-grants-2006_03
Patent number
US07015328B2

Reaction notes

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