反应详情

To ethanol (30 ml) were added 4-fluorophenylhydrazine (7.75 g) and ethyl ethoxymethylenemalonate (2.5 g), and the mixture was refluxed for 3 h. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the residue to allow crystallization. The crystals were recrystallized from a mixed solvent of ethyl acetate-diisopropyl ether to give the title compound (2.5 g), melting point: 127–128° C.

1. temperaturethe mixture was refluxed for 3 h
2. customThe solvent was evaporated under reduced pressure and diisopropyl ether
3. additionwas added to the residue
4. customcrystallization
5. customThe crystals were recrystallized from a mixed solvent of ethyl acetate-diisopropyl ether