反应详情

Subsequently, a catalytic amount of potassium iodide was added to 4-neopentyloxynitrobenzene (69 g), and bromine (66 g) was added dropwise at 60° C. The mixture was stirred for 5 h. The reaction mixture was poured into water and extracted with toluene. The organic layer was washed with aqueous sodium sulfite solution, dried over anhydrous magnesium sulfate, after which the solvent was evaporated under reduced pressure. The residue was recrystallized from n-hexane to give 3-bromo-4-neopentyloxynitrobenzene (80 g), melting point: 86–88° C.

1. additionwas added dropwise at 60° C
2. extractionextracted with toluene
3. washThe organic layer was washed with aqueous sodium sulfite solution
4. dry with materialdried over anhydrous magnesium sulfate
5. customafter which the solvent was evaporated under reduced pressure
6. customThe residue was recrystallized from n-hexane