Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiomorpholine → 5-Amino-2-(4-thiomorpholinopiperidin-1-yl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiomorpholine | HCID 67164 | — |
| 반응물 | 5-Nitro-2-(4-oxopiperidin-1-yl)benzonitrile | HCID 22227987 | — |
| 생성물 | 5-Amino-2-(4-thiomorpholinopiperidin-1-yl)benzonitrile | HCID 22227879 | — |
반응 단계
Reductive amination was conducted according to J. Org. Chem., vol. 55, p. 2552 (1990) using 5-nitro-2-(4-oxopiperidin-1-yl) benzonitrile and thiomorpholine. Then, the nitro group was reduced in the same manner as in Starting Material Synthesis Example 40 to give the title compound, melting point: 138° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07015218B1 |
| 출처 데이터셋 | uspto-grants-2006_03 |
| ORD ID | ord-245712189b394e28b389c77769030896 |
| 출처 메모 | uspto-grants-2006_03 |