HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butanoic acid, 2-(ethoxymethylene)-3-oxo-, ethyl ester → 5-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butanoic acid, 2-(ethoxymethylene)-3-oxo-, ethyl ester | HCID 97734 | — |
| Reactant | 4-(Trifluoromethyl)phenylhydrazine | HCID 136200 | — |
| Product | 5-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid | HCID 10778429 | 68.9% |
Reaction Steps
By the reaction and treatment in the same manner as in Starting Material Synthesis Example 1 using 4-trifluoromethylphenylhydrazine (12.8 g) and ethyl 2-ethoxymethyleneacetoacetate (12.3 g), the title compound (12.3 g) was obtained, melting point: 181° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-13ba6891e72e4bc0af0e60a030a9b061 |
| Source note | uspto-grants-2006_03 |