HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butanoic acid, 2-(ethoxymethylene)-3-oxo-, ethyl ester → 3-Methyl-1-(phenylmethyl)-1H-pyrazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butanoic acid, 2-(ethoxymethylene)-3-oxo-, ethyl ester | HCID 97734 | — |
| Reactant | Benzylhydrazine dihydrochloride | HCID 146540 | — |
| Product | 3-Methyl-1-(phenylmethyl)-1H-pyrazole-4-carboxylic acid | HCID 542800 | 27.8% |
Reaction Steps
By the reaction and treatment in the same manner as in Starting Material Synthesis Example 1 using benzylhydrazine dihydrochloride (8.0 g) and ethyl 2-ethoxymethyleneacetoacetate (7.6 g), the residue was recrystallized from ethyl acetate to give 1-benzyl-3-methylpyrazole-4-carboxylic acid (2.45 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07015218B1 |
| Source dataset | uspto-grants-2006_03 |
| ORD ID | ord-625383f8b19e4c3999f3c5c5078b4933 |
| Source note | uspto-grants-2006_03 |