5-Chloro-2-nitrobenzonitrile → 2-Amino-5-(4-morpholinopiperidin-1-yl)benzonitrile

HRID 1744544Notes

Reaction equation

HRID 1744544 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-])=O)=[C:6]([CH:9]=1)[C:7]#[N:8].[O:13]1[CH2:18][CH2:17][N:16]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH2:15][CH2:14]1>>[NH2:10][C:5]1[CH:4]=[CH:3][C:2]([N:22]2[CH2:23][CH2:24][CH:19]([N:16]3[CH2:17][CH2:18][O:13][CH2:14][CH2:15]3)[CH2:20][CH2:21]2)=[CH:9][C:6]=1[C:7]#[N:8]

Participants

3

Reactant 2

HCID 1005065-Chloro-2-nitrobenzonitrileHCID 7957244-Morpholinopiperidine

Product 1

HCID 222279972-Amino-5-(4-morpholinopiperidin-1-yl)benzonitrile

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthesis Example 40 using 5-chloro-2-nitrobenzonitrile and 4-morpholinopiperidine, the title compound was obtained, melting point: 178–180° C.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-8bef2050eba6441cbca21025df8abc9d
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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