Benzene, 1-chloro-2-methyl-4-nitro- → 3-Methyl-4-(4-morpholinopiperidin-1-yl)aniline

HRID 1744546Notes

Reaction equation

HRID 1744546 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[CH3:11].[O:12]1[CH2:17][CH2:16][N:15]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH2:14][CH2:13]1>>[CH3:11][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:2]=1[N:21]1[CH2:22][CH2:23][CH:18]([N:15]2[CH2:16][CH2:17][O:12][CH2:13][CH2:14]2)[CH2:19][CH2:20]1)[NH2:8]

Participants

3

Reactant 2

HCID 83315Benzene, 1-chloro-2-methyl-4-nitro-HCID 7957244-Morpholinopiperidine

Product 1

HCID 222279093-Methyl-4-(4-morpholinopiperidin-1-yl)aniline

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthesis Example 40 using 4-chloro-3-methylnitrobenzene and 4-morpholinopiperidine, the title compound was obtained, melting point: 199–200° C.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-c142c0aad2ac43b4b36855b780cfe3fe
Source dataset
uspto-grants-2006_03
Patent number
US07015218B1

Reaction notes

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